Role of the Multidisciplinary Care Team

A multidisciplinary team approach is recommended when treating myelodysplastic syndromes...

Myelodysplastic Syndromes (MDS) Overview

MDS refers to a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders, resulting from...

Stem Cell Dysfunction

Stem cell dysfunction in myelodysplastic syndromes (MDS) leads to abnormal cell development...

The Progression to Myelodysplastic Syndromes (MDS)

There are several pre-MDS disorders that share some characteristics of MDS (clonality, dysplasia...

Chromosomal, Epigenetic, and Mutational Abnormalities

Myelodysplastic syndromes (MDS) are influenced by a number of chromosomal, epigenetic, or...

Normal Blood Cell Development

An important part of treating patients with myelodysplastic syndromes (MDS) is understanding their...

Understanding Erythropoiesis

Erythropoiesis is defined as the process through which the body produces red blood cells (RBCs). On average...

Ineffective Erythropoiesis (IE)

IE is characterized by increased proliferation of erythroid progenitor cells, abnormal differentiation...

Myelodysplastic Syndromes (MDS) Epidemiology

Estimates of the prevalence of MDS vary between 50,000 and 170,000 people, with diagnostic criteria...

Clinical Features of Myelodysplastic Syndromes (MDS)

MDS have a heterogeneous patient population. While they occur predominantly in the elderly, they...

Cytopenias and Qualitative Defects in Blood Cell Function

Patients with myelodysplastic syndromes (MDS) experience significant cytopenias, which are typically...

Differential Diagnosis

Given the heterogeneity of myelodysplastic syndromes (MDS), as well as the clinical and...

Diagnostic Workup for Myelodysplastic Syndromes (MDS)

Minimum diagnostic criteria for MDS include 2 prerequisites...

Bone Marrow Analysis

Bone marrow testing is an important part of diagnosing myelodysplastic syndromes (MDS)...

Cytogenetic Evaluation

Cytogenetics are important prognostic indicators of myelodysplastic syndromes (MDS) and...

Cytogenetic Profiles and Prognostic Importance

Cytogenetic analysis remains one of the most important diagnostic and prognostic tools in patients...

Molecular Analysis

Genetic analyses have identified mutations in genes central to the pathogenesis of myelodysplastic...

Overview of Classification Systems

Myelodysplastic syndromes (MDS) constitute a complex hematological disorder that gives...

2016 World Health Organization (WHO) Classification

The WHO recognizes 6 main types of myelodysplastic syndromes (MDS) and distinguishes...

Overview of Prognostic Systems

Prognostic systems aim at improving the ability to predict survival and progression in patients...

Revised International Prognostic Scoring System (IPSS-R)

The IPSS-R, which is the most commonly used scoring system, is a refinement of the original...

Distribution of Prognostic Scores at the Time of Diagnosis

Using the IPSS-R at time of diagnosis (evaluated in the diagnosed patient cohort; N=7012) for the...

Palliative Care

Patients with myelodysplastic syndromes (MDS) may have multidimensional supportive care...

Supporting Caregivers

The establishment of a patient-caregiver partnership and effective communication among patients...

Treating Myelodysplastic Syndromes (MDS)

Treatment goals for MDS should follow a risk-adapted approach based on the risk category...

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