The diagnosis of MZL follows a similar workup for diagnosing other subtypes of Non-Hodgkin’s Lymphoma (NHL).1
- Evaluation of symptoms – onset, behavior, presence of B-cell symptoms (recurring fever, drenching night sweats, significant weight loss)2
- Review of systems, noting any recent changes or infections1
- Quantifying performance status1
- Determining risk factors for NHL2
| Physical Examination | The essential workup for MZL includes a physical exam with assessment of performance status.1 |
| Laboratory Workup | Certain laboratory studies are essential in patients suspected of having MZL. Additional studies may be informative in specific clinical situations, depending on findings from the history and physical exam.1 |
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Histology: |
Immunophenotyping is required to establish a diagnosis of MZL. Cytogenetic analyses and molecular analysis may be used to detect additional mutations associated with MZL.1 |
| Immunophenotyping Cytogenetics Molecular Profiling |
NHL is complex, requiring physicians to differentiate among many different subtypes.3 Biopsies of the lymph node or other disease site can be used to help identify MZL. Bone marrow biopsy + aspirate is required to accurately determine disease stage.1 |
| Imaging Studies | Imaging is essential for diagnosing MZL.1 |
NCCN, National Comprehensive Cancer Network.