What Is Lymphoma?

“Lymphoma” is the general term for a heterogeneous group of cancers that arise from lymphocytes...

What Is Marginal Zone Lymphoma (MZL)?

MZL is an indolent (slow-growing) non-Hodgkin lymphoma (iNHL) that arises from B cells in the...

Pathogenesis of Marginal Zone Lymphoma (MZL)

MZL is thought to arise due to chronic immune stimulation. This may be due to infections...

Clinical Presentation of Marginal Zone Lymphoma (MZL)

MZL can involve many different tissues in the body, including the stomach, thoracic or abdominal lymph nodes...

Initial Diagnostic Workup of Marginal Zone Lymphoma (MZL)

The diagnosis of MZL follows a similar workup for diagnosing other subtypes of Non-Hodgkin’s Lymphoma...

Physical Examination

A thorough physical examination of the patient should be conducted with an assessment of performance status...

Laboratory Workup

Essential laboratory tests in the initial diagnostic workup of marginal zone lymphoma are...

Biopsy and Histology

Excisional biopsy (entire lymph node removed) is recommended to establish...

Immunophenotyping, Cytogenetic, and Mutational Analysis

Immunophenotyping refers to tests used to identify unique cell types based on the types of antigens...

Imaging Studies

Imaging studies—such as PET/CT and CT scans—have become the standards that provide a baseline...

Risk Factors for Marginal Zone Lymphoma (MZL)

The etiology of MZL is poorly understood; however, it has been suggested that certain infections...

Staging of Marginal Zone Lymphoma (MZL)

Staging in nodal MZL is performed using the Lugano modification of the Ann Arbor staging system...

Prognosis of Marginal Zone Lymphoma (MZL)

NHL subtype, disease stage, and disease grade are all associated with each patient’s prognosis...

Treating Marginal Zone Lymphoma (MZL)

The GELF Criteria were established in follicular lymphoma to help define patients with high tumor burden...

Supportive Care for Lymphoma

Supportive care in cancer is the prevention and management of symptoms and side effects...

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