Clinical Presentation of Follicular Lymphoma (FL)

Patients with FL typically present with painless lymphadenopathy, commonly appearing as enlargement of lymph nodes, typically in the neck, underarms, abdomen, or groin.1,2

Bone marrow involvement is present in 70% of patients and involvement of other organs is uncommon.1

<20% of patients experience B symptoms.1

  • B symptoms include recurrent fever, drenching night sweats, and significant weight loss3

<20% of patients have increased serum LDH.1

  • LDH is an enzyme involved in glycolysis, which is a fast but inefficient type of cell metabolism preferentially used by cancer cells to fuel rapid growth3
  • LDH is a marker that can be detected in the blood that is associated with increased cancer burden, worse OS, and reduced response to therapy in many different tumor types, including lymphoma4

FL, follicular lymphoma; LDH, lactate dehydrogenase; OS, overall survival.

References: 1. Freedman A. Follicular Lymphoma: 2018 Update on Diagnosis and Management. Am J Hematol. 2018;93:296-305. 2. Lymphoma Research Foundation. Follicular Lymphoma. Accessed September 24, 2018. 3. Valvona CJ, Fillmore HL, Nunn PB, Pilkington GJ. The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor. Brain Pathology. 2016;26:3-17. 4. Miao P, Sheng S, Sun X, Liu J, Huang G. Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy. IUBMB Life. 2013;65(11):904-910.