Acute Myeloid Leukemia (AML) Epidemiology


While AML is the most common acute leukemia in adults, it is a relatively rare cancer.2,4 AML represents an estimated 1.1% of all new cancer cases and 1.9% of all cancer deaths in the United States in 2021.1 Incidence rates are higher in men.1

  • Between 2014 and 2018, new cases of AML were more common among men than women (5.2 vs 3.6 cases per 100,000 people)
  • Between 2014 and 2018, the number of new age-adjusted cases of AML was 4.3 per 100,000 men and women per year

The median age at AML diagnosis is 68 years and incidence rates tend to increase with age. Death rates are also higher in patients age 65-84 years.1

AML made up 48% of all estimated leukemia-related deaths for both men and women, 2.1% of all estimated cancer deaths in men, and 1.7% of all estimated cancer deaths in women in 2018.5

Relapse in Acute Myeloid Leukemia (AML)

Image above created with BioRender.com

References: 1. Cancer Stat Facts: Leukemia - Acute Myeloid Leukemia (AML). National Cancer Institute website. http://seer.cancer.gov/statfacts/html/amyl.html. Accessed April 22, 2021. 2. De Kouchkovsky I, Abdul-hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J. 2016;6(7):e441. 3. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71(1):7‐33. 4. Burnett A, Wetzler M, Löwenberg B. Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 2011;29(5):487-494. 5. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review (CSR) 1975-2018. National Cancer Institute website. https://seer.cancer.gov/csr/1975_2018/. Published April 15, 2021. Accessed July 29, 2021. 6. Rӧllig C, Kramer M, Gabrecht M, et al. Intermediate-dose cytarabine plus mitoxantrone versus standard-dose cytarabine plus daunorubicin for acute myeloid leukemia in elderly patients. Ann Oncol. 2018;29(4):973-978. 7. Verma D, Kantarjian H, Faderl S, et al. Late relapses in acute myeloid leukemia: analysis of characteristics and outcome. Leuk Lymphoma. 2010;51(5):778-782.