Sepsis/Neutropenic Fever

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to bacterial infection
  • Septic Shock is a type of vasodilatory and distributive shock defined as: sepsis that has circulatory, cellular, and metabolic abnormalities associated with greater risk of mortality than sepsis alone

Clinical presentation includes1:

  • Symptoms and signs specific to causative infectious source
  • Arterial hypotension: Systolic blood pressure <90 mmHg, mean arterial pressure <70 mmHg, SBP decrease >40 mmHg, or <2 standard deviations below normal for age
  • Heart rate >90 bpm or >2 standard deviations above normal value for age
  • Respiratory rate >20 breaths/minute
  • Temperature >38.3°C (100.9°F) or <36°C (96.8°F)
  • Signs of end-organ perfusion: Decreased capillary refill, cyanosis or mottling, additional signs of hypoperfusion including altered mental status, obtundation or restlessness, oliguria or anuria, ileus or absent bowel sounds are an end-stage sign of hypoperfusion
  • Altered mental status
  • Delirium
  • Agitation
  • Drowsiness/sluggishness
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Reference: 1. Neviere R. Sepsis syndromes in adults: epidemiology, definitions, clinical presentation, diagnosis, and prognosis. UpToDate website. https://www.uptodate.com/contents/sepsis-syndromes-in-adults-epidemiology-definitions-clinical-presentation-diagnosis-and-prognosis. Updated February 3, 2020. Accessed April 22, 2021.