- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to bacterial infection
- Septic Shock is a type of vasodilatory and distributive shock defined as: sepsis that has circulatory, cellular, and metabolic abnormalities associated with greater risk of mortality than sepsis alone
Clinical presentation includes1:
- Symptoms and signs specific to causative infectious source
- Arterial hypotension: Systolic blood pressure <90 mmHg, mean arterial pressure <70 mmHg, SBP decrease >40 mmHg, or <2 standard deviations below normal for age
- Heart rate >90 bpm or >2 standard deviations above normal value for age
- Respiratory rate >20 breaths/minute
- Temperature >38.3°C (100.9°F) or <36°C (96.8°F)
- Signs of end-organ perfusion: Decreased capillary refill, cyanosis or mottling, additional signs of hypoperfusion including altered mental status, obtundation or restlessness, oliguria or anuria, ileus or absent bowel sounds are an end-stage sign of hypoperfusion
- Altered mental status
- Delirium
- Agitation
- Drowsiness/sluggishness
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