Clinical Presentation of Acute Myeloid Leukemia (AML)

Patients with AML generally present with symptoms related to leukemic infiltration of the bone marrow, including1:

  • Fatigue
  • Dyspnea on exertion
  • Infections and fever
  • Bleeding disorders

It is likely that most patients have had more subtle evidence of leukemia for weeks, or perhaps months, before diagnosis.2

Clinical Features and Patient Presentations of AML1-4

 

References: 1. Kabel AM, Zamzami F, Al-Talhi M, Al-Dwila K, Hamza R. Acute myeloid leukemia: a focus on risk factors, clinical presentation, diagnosis and possible lines of management. J Cancer Res Treat. 2017;5(2):62-67. 2. Schiffer CA, Stone RM. Presenting signs and symptoms. In: Kufe DW, Pollock RE, Weichselbaum RR, et al, eds. Holland-Frei Cancer Medicine. 6th ed. Hamilton, ON: BC Decker; 2003. https://www.ncbi.nlm.nih.gov/books/NBK14008/. Accessed January 22, 2019. 3. Davis AD, Viera AJ, Mead MD. Leukemia: an overview for primary care. Am Fam Physician. 2014;89(9):731-738. 4. Chen CY, Cheng A, Huang SY, et al. Clinical and microbiological characteristics of perianal infections in adult patients with acute leukemia. PLoS One. 2013;8(4):e60624.