Clinical Manifestations Overview

Blasts Reduce the Number of Healthy Blood Cells in AML

In normal healthy bone marrow, blast percentage is typically <5% and there should be no blasts in the peripheral blood.1

  • In AML, the unregulated growth and proliferation of leukemic blasts crowd out the bone marrow space for production of healthy cells, thereby reducing the number of red blood cells, white blood cells, and/or platelets2
  • Pancytopenia occurs when red blood cell, white blood cell, and platelet counts are all low in a patient2

Clinical Manifestations Associated With AML

Clinical manifestations associated with AML are noted in the figure below. While anemia, thrombocytopenia, neutropenia, leukostasis, and organ infiltration are common, central nervous system involvement is uncommon3:

Image above created with BioRender.com

References: 1. Tests for Acute Myeloid Leukemia (AML). American Cancer Society website. https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-diagnosed.html. Updated August 21, 2018. Accessed April 22, 2021. 2. Acute Myeloid Leukemia (AML). Leukemia & Lymphoma Society website. https://www.lls.org/leukemia/acute-myeloid-leukemia. Accessed April 22, 2021. 3. Cheng CL, Li CC, Hou HA, et al. Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults. BMC Cancer. 2015;15:344. 4. Signs and Symptoms of Acute Myeloid Leukemia (AML). American Cancer Society website. http://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/signs-symptoms.html. Updated August 21, 2018. Accessed April 22, 2021. 5. Chen CY, Cheng A, Huang SY, et al. Clinical and microbiological characteristics of perianal infections in adult patients with acute leukemia. PLoS One. 2013;8(4):e60624.