Disease-related Factors Impacting Acute Myeloid Leukemia (AML) Prognosis

Recent years have seen major strides in predicting the outcome of patients with newly diagnosed AML. We now have insights into the1:

  • Cytogenetic and molecular basis of AML
  • Biology of the subtypes of the disease
  • Impact of age, presenting white blood count, and how AML arises (eg, de novo or following an antecedent hematologic disorder or chemotherapy/radiation exposure)

All of these learnings have greatly influenced changes in clinical practice and, consequently, the treatment approach.

To date, the 3 key disease-related factors that affect the prognosis in patients with AML are: abnormal cytogenetics, genetic mutations, and the type of AML.2-4

Disease-related Factors Impacting AML Prognosis

References: 1. Grimwade D, Hills RK. Independent prognostic factors for AML outcome. Hematology Am Soc Hematol Educ Program. 2009:385-395. 2. Foran JM. New prognostic markers in acute myeloid leukemia: perspective from the clinic. Hematology Am Soc Hematol Educ Program. 2010;2010:47-55. 3. Welch JS, Ley TJ, Miller CA, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-278. 4. Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol. 2003;21(24):4642-4649.