Acute Myeloid Leukemia (AML) Overview

AML is a blood cancer characterized by an infiltration of the bone marrow, blood...

Acute Myeloid Leukemia (AML) Risk Factors

One study of 3363 AML registry patients reported that about three-quarters of all cases of AML arose de novo...

Clinical Presentation

Patients with acute myeloid leukemia (AML) may present with varying combinations of the following clinical...

Acute Myeloid Leukemia (AML) Epidemiology

Key statistics for acute myeloid leukemia...

Clinical Presentation of Acute Myeloid Leukemia (AML)

Patients with AML generally present with symptoms related to leukemic infiltration of the bone...

Criteria for an Acute Myeloid Leukemia (AML) Diagnosis

In accordance with the 2016 World Health Organization (WHO) classification, a diagnosis of AML...

Initial Diagnostic Workup for Acute Myeloid Leukemia (AML)

The 2019 National Comprehensive Cancer Network (NCCN) Guidelines recommend a comprehensive...

Physical Exam and History

At diagnosis, a detailed medical history should be obtained, including the patient's health habits...

Laboratory Blood Tests to Help Confirm Acute Myeloid Leukemia (AML)

See article for Laboratory Blood Tests to Help Confirm Acute Myeloid Leukemia (AML)...

Bone Marrow Analysis

Bone marrow analysis with cytogenetics (karyotype, with or without fluorescence...

Immunophenotyping

For more than a decade, flow cytometric immunophenotyping has been an indispensable diagnostic tool...

Cytogenetics

Karyotyping or routine cytogenetic analysis helps detect clonal aberrations...

Molecular Markers and Risk

Molecular profiling has the ability to identify mutations that correlate to prognostic and predictive...

Next Generation Genome Sequencing (NGS)

NGS has been used to identify rare variants in patient cohorts and to classify genomes...

Disease-related Factors Impacting Acute Myeloid Leukemia (AML) Prognosis

Recent years have seen major strides in predicting the outcome of patients with newly diagnosed AML...

Clinical Impact of Abnormal Cytogenetics in Acute Myeloid Leukemia (AML)

AML (there is more than one type) and myelodysplastic syndromes (MDS) harbor...

World Health Organization (WHO) 2016 Acute Myeloid Leukemia (AML) Classification Scheme

AML is a genetically and molecularly heterogeneous disease...

Genetic Abnormalities and Risk Status

The use of molecular profiling alongside cytogenetics is improving our ability to identify mutations...

Clinical Implications of Genetic and Molecular Abnormalities

In recent years, gene mutations and deregulated expression of genes...

Acute Myeloid Leukemia (AML) Prognosis

Findings from cytogenetic and molecular analysis of the bone marrow are important...

Treatment Goals in Acute Myeloid Leukemia (AML)

Generally, AML treatment is divided into 2 phases: remission induction therapy and post-remission therapy...

Pretreatment Evaluation

There are several things to consider before determining a treatment for your patients with acute myeloid leukemia (AML)...

Treatment Considerations

According to the National Comprehensive Cancer Network (NCCN) guidelines, most initial treatment...

Stem Cell Transplantation

Post-remission therapy with allogeneic hematopoietic-cell transplantation (allo-HCT) offers the most...

Treatment Response

Unless clinical trials include head-to-head comparisons, determining the relative efficacy of acute...

An Overview: Supportive Care, Complications, and Oncologic Emergencies

Both acute myeloid leukemia (AML) and its treatment can cause complications...

Complications of Acute Myeloid Leukemia (AML)

Anemia often complicates the course of cancer. While anemia may be a presenting sign of malignancy, it may...

Addressing Oncologic Emergencies

Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency in patients with...

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