Acute Myeloid Leukemia (AML) Overview

AML is a potentially curable hematologic malignancy that stems from immature myeloid progenitor cells...

Acute Myeloid Leukemia (AML) Epidemiology

While AML is the most common acute leukemia in adults, it is a relatively rare cancer...

Types of Acute Myeloid Leukemia (AML) and Associated Risk Factors

A study of 3363 Swedish AML registry patients found that about three-quarters of all cases of AML arose de novo...

Acute Myeloid Leukemia (AML) Pathogenesis

In normal hematopoiesis, pluripotent hematopoietic stem cells (HSCs) give rise to all of the different...

Clinical Manifestations Overview

In normal healthy bone marrow, blast percentage is typically <5% and there should be no blasts in…

Evaluating Signs and Symptoms

The following section includes common signs and symptoms associated with AML. Not all symptoms...

Initial Diagnostic Workup for Acute Myeloid Leukemia (AML) in Adult Patients

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) initial evaluation includes...

Physical Exam and History

At diagnosis, a detailed medical history should be obtained, including the patient's health habits...

Laboratory Blood Tests to Help Confirm Acute Myeloid Leukemia (AML)

See resource for Laboratory Blood Tests to Help Confirm Acute Myeloid Leukemia (AML)...

Bone Marrow Analysis

Blast percentages in peripheral blood and bone marrow are determined by microscopic visualization...

Immunophenotyping

Immunophenotyping is used to identify antigens, or markers, expressed on the outside of the cell...

Cytogenetics

FISH is a cytogenetic method that uses fluorescent probes for the visual detection of specific structural...

Molecular Testing

Whereas cytogenetic analysis can screen for chromosomal abnormalities, molecular profiling...

Potential Clinical Impact of Genetic Mutations in Acute Myeloid Leukemia (AML)1-3

See resource for Potential Clinical Impact of Genetic Mutations in Acute Myeloid Leukemia (AML)...

Acute Myeloid Leukemia (AML) Classification

Beginning in the 1970s, AML was classified according to the FAB (French-American-British) system...

Disease-Related Factors Impacting Acute Myeloid Leukemia (AML) Prognosis1,2

AML is a heterogeneic disease associated with varied abnormal cytogenetics, specific gene mutations...

Genetic Abnormalities and Risk Status

The use of molecular profiling alongside cytogenetics is improving our ability to identify mutations that...

Clinical Implications of Genetic and Molecular Abnormalities

In recent years, gene mutations and deregulated expression of genes and noncoding RNAs...

Acute Myeloid Leukemia (AML) Prognosis

In this analysis, patient prognosis is determined by cytogenetic risk group and type of AML...

Treatment Goals in Acute Myeloid Leukemia (AML)

Generally, AML treatment is divided into 2 phases: remission induction therapy and post-remission therapy...

Pretreatment Evaluation

There are several things to consider before determining a treatment for your patients with acute myeloid leukemia (AML)...

Newly Diagnosed Acute Myeloid Leukemia (AML) Treatment Considerations

NCCN Guidelines group first-line treatment options into three groups...

Treatment Response

There are several levels of response to treatment in AML (ie, CR, MLFS, and PR)...

Checklist for Managing Patients With Acute Myeloid Leukemia (AML)1,2

If patients are treated in the outpatient setting, active participation of patients and...

Complications of Acute Myeloid Leukemia (AML)

Anemia often complicates the course of cancer. While anemia may be a presenting sign of malignancy, it may...

Factors Influencing Patient Adherence in Acute Myeloid Leukemia (AML)

Factors influencing adherence may include, but are not limited to...

Disease Assessment After Treatment

After first-line treatment and upon hematologic recovery, bone marrow aspirate and biopsy are...

Measurable Residual Disease (MRD) and Assessment Types

Patients who achieve a CR are still at risk for relapse, and this is influenced by the amount of measurable...

Consolidation Therapy

Consolidation therapy may be given following induction chemotherapy to help eliminate any AML cells...

Continued Treatment and Maintenance Therapy

According to the FDA, continued treatment in AML is an extended course of treatment...

Treatment Options for Relapsed/Refractory Acute Myeloid Leukemia (AML)1,2

There are limited treatment options for patients following induction failure. Treatment...

Potential Oncologic Emergencies1,2

Certain oncologic emergencies may develop due to AML disease or treatment...

Stem Cell Transplant

Post-remission therapy with allogeneic hematopoietic-cell transplant (alloHSCT) is a potentially curative therapy...

Role of the Patient Caregiver in Acute Myeloid Leukemia (AML)1

An involved caregiver acts as an important liaison between the healthcare team and patient...

Tumor Lysis Syndrome (TLS)

TLS occurs when a large number of tumor cells are killed in a short period of time...

Leukostasis1

Hyperleukocytosis is a laboratory abnormality that has been variably defined as...

Sepsis/Neutropenic Fever

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...

Disseminated Intravascular Coagulation (DIC)1

In disseminated intravascular coagulation, or DIC, the processes of coagulation and fibrinolysis become...

Differentiation Syndrome (DS)1

DS is a potentially fatal complication of treatment with differentiating agents...

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